In some ways, Orgovyx is more effective than Lupron — as a GnRH agonist, Lupron creates an initial testosterone surge that can trigger more even cancer spread before the testosterone suppression starts. As a GnRH antagonist, Orgovyx starts working immediately, which is crucial if your cancer is aggressive.

Note that you can prevent Lupron's initial testosterone surge using bicalutamide or flutamide, but it still doesn't start actually working to *suppress* testosterone until the surge would have been finished, so it's not the best initial treatment for urgent, fast moving cancer like mine. That's why my medical team started me on Firmagon (a GnRH antagonist like Orgovyx, but as an injection) back in 2021, when Orgovyx wasn't approved yet in Canada.