Wow after reading post from monimoa thought at first was reading my history however older than you I think. But so similar - my hormone positive breast cancer showed up in my lymph nodes under my left arm area 20+ years later, even with aggressive treatment with double mastectomy, clear nodes and tamoxifen for 5 years returned as stage 3. My current surgeon said it is nearly impossible to get ever cancer cell - but the surprise was the recurrence in the lymph nodes after so many years. Currently on a hormone inhibitor and after 6 month there was significant reduction of cancer activity showing on the MRI. I then had surgery where they removed 27 nodes and 11 nodes still showed with cancer cells. After surgery also had 16 rounds of radiation for mop up. Now my oncologists want me to take CDK 4/6 for 2 or 3 years - I did try Verzenio for 1 month - made me very sick with negative blood tests. I stopped the drug. I have major questions about "cancer" treatments and why oncology is so determined to weaken/destroyed my immunity when it is already struggling with a cancer return/my immunity had kept the cancer in remission for years - guess with age our immune system declines but seems a better treatment would involve strengthening my immune system instead of destroying it. I feel if I allow oncology to further destroy my own immune system - once treatments finish my cancer will return with a vengeance and have no ability to fight it. I visit my oncologist next week and have questions about getting my immune system up to speed - hope they might offer me Anktiva now a FDA-approved immunotherapy designed to activate the body's natural immune system to target and attack cancer cells. Would love to hear if others are looking in to similar therapy/treatments.