It's because of the rebound effect. During your time on Prolia, your body continues to produce the bone-breakdown cells called osteoclasts but they don't mature fully. Instead, they accumulate and when you stop the drug, they develop to maturity and go to work breaking down bone. This flurry of bone destruction weakens your bones and can cause multiple fractures soon after stopping the drug.

This means you must stay on the drug for the rest of your life or go through more treatment with other drugs like Reclast or alendronate if you come off Prolia.

I am 64 and hopefully have many more years to live and deal with this disease. I think there is a time and a place for Prolia but I hope to push it out as long as I can.