I’ve been castrate resistant for six years. I did have one metastasis zapped on my spine. I’ve been undetectable for the last 20 months on Nubeqa and Orgovyx. 15 years with PC.

If I get another metastasis, I would get it zapped. I’ve already had surgery and salvage radiation.

The drugs we have now work quite well with people that are castrate resistant.

If you met me, you would have no idea I had cancer, I’m 77 and quite active.

Sorry--I don't want private messages; that setting is intentional. My husband was first diagnosed and treated locally in 2005, and had his first recurrence in 2011, when he was declared to be Stage 4 after metastases were found on his spine at Mayo Rochester. I can't pinpoint exactly when he became castrate resistant, other than to say it has been years ago now, so can't tell you how things might have changed for him at that point. As for his journey so far, he has had external beam radiation, brachytherapy, several rounds of SBRT, docetaxel chemotherapy, Pluvicto, Zytiga, Lupron, and probably some other treatments which I have forgotten.

If you have specific questions about becoming or being castrate resistant, I would urge you to go ahead and post them on this forum. I am sure many who read and post here could answer your questions based on personal experience. Everyone here is generous with their time and experience, and this is a safe place to ask for information and support.