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johndavis60 avatar

Somatic Testing

Prostate Cancer | Last Active: Jul 31 8:03pm | Replies (24)
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I had germline testing that showed no mutations. I also got a foundation one test that showed some BRCA2 mutations. So it was different. My MO said no change to my treatment at this time. It can however help to direct treatment depending on the test results, patient diagnosis and stage.

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Replies to "I had germline testing that showed no mutations. I also got a foundation one test that..."
jeff Marchi | @jeffmarc | Jul 30 10:29am

Somatic findings don’t always stay around, You could have BRCA2 Show up in your somatic test today, a year from now, it might not be there.

The thing is, if it still Shows you have somatic BRCA2 When your current treatment fails, you could start on a PARP Inhibitor.

My GU oncologist has been working with me for about eight years. Even though I am BRCA2 She has had me take other drugs before the PARP inhibitor. It has major side effects so she wants me to avoid it until it is essential. When Darolutamide fails me I will go on a PARP inhibitor.

So what your doctor said makes perfect sense.

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