We all have experienced your concerns in starting Leqembi infusions. My wife is getting ready for her 10th infusion, and it has been relatively easy. She had a significant headache with her first round but then she was told to take a Tylenol about 1 hour before the infusion and we lengthened the time from 1 hour to 1 1/2 hour and everything is going fine. She is tired after the infusion but then fine for the rest of the week. We use a local infusion center so it is quite easy for us.
Hopefully your results will go well also.