← Return to Enhertu treatment and quality of life

Discussion
cookercooker avatar

Enhertu treatment and quality of life

Gynecologic Cancers | Last Active: Dec 11, 2025 | Replies (30)

Comment receiving replies
Profile picture for margitdill @margitdill

Thank you for the feedback on ENHERTU. It is the fifth cancer drug I’ve been given - and for me, the one with the worst side effects. I have not recovered from the first dose … the fatigue, the nausea, the flu-ish feeling have made me bed bound. For me it is unendurable. And I have no quality of life. I think my body is now resisting and rejecting cancer drugs. I am thinking about ceasing treatment soon.

Jump to this post


Replies to "Thank you for the feedback on ENHERTU. It is the fifth cancer drug I’ve been given..."

How long has it been since your first treatment that you're still feeling sick? As I said before be prepared to be sick to your stomach and GI problems. Take the prescribed anti-nausea meds, metacoplomide (sp?), every 4-6 hours with food. I also take a prescribed med to combat acid-reflux, pantoprazole, which I take once a day before I eat breakfast; but you can take another if acid reflux continues.
Fatigue is an ongoing issue; I sleep in the afternoons the first week after treatment. It's hard to resist the bed but I find that if I do, get out in the garden or walk around the house, doing some laundry or walking the dog, I feel a little more energized.
Enhertu may or may not be for you. But your oncologist should be monitoring you closely. Keep him/her informed if you don't get the attention and relief you deserve. Don't give up!

@margitdill I’m in a similar diagnosis, also with limited treatment options and feeling unhappy about my quality of life on ENHERTU. I get my 1st CT tomorrow after 3 rounds on it. You’re not alone in your side effects and questions about what’s next if not ENHERTU.