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Profile picture for jeff Marchi @jeffmarc

I just realized that you were on a PARP Inhibitor (Talzenna). They are only usable for people that have BRCA in either their hereditary or somatic tests.

Do you have BRCA2 or BRCA1? If not, then the PARP Inhibitor is doing nothing but costing money and your side effects due to it. It does have a lot of issues with your white blood cell counts and hemoglobin.

I have BRCA2 And plan on using a PARP Inhibitor when Darolutamide fails me.

If you do not have BRCA, you should get off of Talzenna. I would be very suspicious of any doctor that prescribed this for someone that doesn’t have BRCA, Since that is the only thing it works with. Some doctors have tried to use it for people that have ATM, but it does not work.

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Replies to "I just realized that you were on a PARP Inhibitor (Talzenna). They are only usable for..."

There have been clinical trials investigating using PARP inhibitors in combination with ADT+ARSIto treat mCRPC, regardless of germline mutations, but I don't think any has made it into mainstream care yet.

Example:
https://evidence.nejm.org/doi/full/10.1056/EVIDoa2200043