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Is there an average and/or an expected drop in PSA after Lupron shot?

Prostate Cancer | Last Active: Jul 30, 2025 | Replies (36)
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Profile picture for olman @olman

Hi Jeff,
I never heard of “ castrate resistant “ until I read it here. None of my doctors ever mentioned it to me.
I’m guessing that it means pills no longer do what they are suppose to do. Is that what it means?

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Replies to "Hi Jeff, I never heard of “ castrate resistant “ until I read it here. None..."
jeff Marchi | @jeffmarc | Jul 28, 2025

Yes.

If somebody is on ADT within 2 to 3 years, they are most likely to find that the drug no longer keeps their PSA down. At that point, they are castrate resistant and need the second drug an ARSI.

I became castrate resistant 2 1/2 years after I started Lupron, almost exactly 6 years ago. Talk about textbook case, dead in the middle of the normal time.

I have remained undetectable for the last 20 months after 15 years of PC.

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