Funny how this stuff changes your life and then you sort of get used to it. I'm now in my 8th month of doublet therapy with quarterly injections of Lupron and daily doses of Erleada, and most nights I'm up 3-4 times to pee. It's a minor annoyance, and I'm usually able to go right back to sleep after I go. Since I'm 83 it's hard to tell how much of this is due to the meds and how much is due to being a codger with weak bladder control. Started on daddy diapers about two years ago. Before then I couldn't imagine myself wearing them, but again, you learn to go with the flow. Pun intended.