Last fall, I was diagnosed with MAC with a large cavity. I started the Big 3 (daily) in November, plus 3 months of IV Amikacin 3 times per week. I was terrified of the disease and the treatment, like you are. I’m 54 years old, married with grown children, and I work full time in a job I love. I have had no side effects from the treatment and I’ve continued to work full time. The PICC line for the IV was inconvenient but I got through it. I did my IV treatments at work (when a nurse came once a week to draw blood and change my bandage) and at home at night on the days the nurse didn’t come. The IV pharmacy shipped the Amikacin and IV supplies to my house and provided the nurse. My sputum samples have been negative since December and my CT scan in June showed the cavity has filled in. I will continue to take the Big 3 every day until this December. I recently started using a nebulizer with 7% saline every day for airway clearance to hopefully reduce my chances of ever getting MAC again. This forum has been a godsend for me. I’ve never posted before but thought you may want to hear from someone who has had a positive experience with the treatment plan you’re facing. I have been fortunate that I’ve been able to continue to live my life, work, and do everything I was doing before my diagnosis throughout my treatment. Best wishes to you as you start this journey!