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Replies to "I’m still so anxious and depressed. Have increased heart rate, dry mouth and constipation. Just started..."
Depression & Anxiety | Last Active: Jul 27, 2025 | Replies (14)
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I’m still so anxious and depressed. Have increased heart rate, dry mouth and constipation. Just started week 6 and increased to 30mg. Going slow due to nausea.
Replies to "I’m still so anxious and depressed. Have increased heart rate, dry mouth and constipation. Just started..."
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@mlpbob It sounds like your prescribing physician is starting you on a low dose. Dry mouth and constipation are the side effects I'd expect from this kind of medication that is anticholinergic.
Here are the side effects of desipramine and other similar medications which are called "tricyclic antidepressants". Scroll to the bottom of the page and you will see that the side effects you describe are on this list.
-- Tricyclic Antidepressants Cleveland Clinic:
-- https://my.clevelandclinic.org/health/treatments/25146-tricyclic-antidepressants
Have you talked with your prescribing physician about your concerns?