Not much can be done about the adrenal suppression and a low cortisol level. It is another side effect of long term Prednisone use. The recommendation is to slowly taper off Prednisone which just prolongs the time we need Prednisone.

People think a slow taper is to prevent flares. However, a slow taper is mostly done to give the adrenals time to recover from Prednisone use.

In the past, if PMR was still active we needed to stay on Prednisone regardless of adrenal suppression. With Actemra and other treatments which achieve remission quicker without adrenal suppression then it should make it easier to achieve a "steroid free sustained remission."

I currently do monthly infusions of Actemra for PMR. I got off Prednisone almost 5 years ago, Most of my side effects from being on prednisone for 12 years have improved tremendously.