@mlpbob @olman Desipramine is an older antidepressant that has been around since before the SSRIs like Prozac became available.

Mayo Clinic: Desipramine

— https://www.mayoclinic.org/drugs-supplements/desipramine-oral-route/description/drg-20071955

I was prescribed despiramine in the 1990’s by my psychiatrist. It worked for me as I was depressed and having panic attacks. I still experienced some anxiety but the desipramine brought the anxiety down to a very manageable level for me. The only side effect I experienced was feeling thirsty as this medication and others like it have an anticholinergic effect much like you might have experienced if you ever took Benadryl.

How are you feeling on the desipramine?