I haven't experience any significant side-effects from Trikafta in the four years I've been taking it. You've probably been warned already about the "purging" that you will experience during the first few days on the drug ...expelling a LOT of mucus from your lungs! My bloodwork also indicates macrocytic anemia, which has worsened since I started Trikafta, but I don't know if that's simply coincidental or a side-effect of the drug; nobody has been very concerned about it. I hope the Trikafta gives you some relief; it certainly did for me. Before starting it, I couldn't lie down to go to sleep at night without first going through a 30-minute coughing fit. Now I rarely have any coughing, day or night!