Kisqali and Letrozole have heart issues?

DCIS 1a with invasive cells -- Oncotype, score 29. Hope to start Kisqali (ribociclib) 400 mg next week. Also taking Anastrozole. Has anyone taking Kisqali (ribociclib) had problems with tinnitus--either getting it or having existing tinnitus greatly increased?
Many thanks!

@peggydobbs
I’ve had tinnitus for over 50 years. I’ve been taking Kisqali 400 and Letrozole for 4 years now and those meds have had no impact on my tinnitus. Best of luck!

@canderson5
What is your current status with Kisqali and your heart? My afib just keeps advancing. I’m in afib 30% of the time now which is really impacting my quality of life. Those days are just wasted. Considering cardiac ablation now but added risk for me due to other conditions. Since I believe Kisqali started it I’m wondering if lowering my dose to 200 mg a day would stop it or if it’s too late at this point. Then I would worry if 200 mg is really even an effective dose.

Is anyone on only 200 mg of Kisqali? How long? Did I reduce side effects or effectiveness? Kisqali 400 mg and Letrozole have been effective for 4.5 years so I really don’t want to rock the boat.

I have afib. My onc wanted me on Kisqali, I said no because of the possible heart issues.
I switched oncs.
Im on exemestane and Verzenio.

I found with my afib, dehydration was an issue, especially in summer.
I have some grey Celtic salt i put under my tongue, about 4-5 little chunks, keep them in my mouth for about 10 seconds then drink some water.. I do this when I know im going out in the heat as a preventative measure. I also take it when my lips feel dry.
It has helped with hydration quite a bit and my afib episodes are minimal.
I bought the cheapest Kardia recommended by my cardiologist.( Bestbuy) I carry my ipad and the Kardia with me at all times as well. Very helpful to record the ekg reports and monitor the duration.
I keep a prescription bottle filled with the Celtic salt in my purse and carry it with me at all times. Dehydration creeps up on me. I also carry an 8 ounce bottle of water in my purse at all times with the Diltiazem.
For me, the choice was cancer over the heart.

Thank you for your response. I do drink a lot of water most days. I’ll have to look into the Celtic salt. I did buy Kardia mobile recently just to document episodes for my cardiologist. Then he put me on a heart monitor for 9 days and it showed I was in afib 30% of the time with up to 150 bpm although typically not over 125. My resting BPM is low 50s. I’ll be meeting with the EP next. We’ll see what he has to say about some of my unique risks.

You might consider asking your dr if you can go 30 days on the monitor. I believe itll give you and your dr a clearer picture.
I did a 15 day monitor which didnt show much.
However, during the 30 days we noticed a pattern. When I went into full blown afib around 189 into the 200s, I went fast. This was helpful for us to know.
Perhaps your dr will allow you to do another monitor for 30 days.
Best!

@ebtexas55
Thank you for your response and suggestion. I’ve been keeping track myself for 4.5 years since I started Kisqali. I’m fully aware when I’m in afib and feel wiped out. Each year the episodes get more frequent and longer in duration. Currently I’m going into afib once sometimes twice a week for 30-60 hours each time. I’ve identified many food triggers and even exercise but no matter how many triggers I eliminate there seems to be more. It’s progressing and I’m losing 10 days of life each month. I’ve refused treatment for 4.5 years but feel I’m at a tipping point. At this point I don’t think changing cancer meds would even stop it. I think it has progressed too much with too many triggers. Just hoping for a good outcome if we move forward with an ablation and the blood thinner I’ll have to go on for a few months. During the 9 day monitoring I had two episodes about 35 hours each (3 days apart) plus a crazy one minute burst. Maybe other things I didn’t feel. Thanks again.

O my! Youre in real afib mode, Zebra. And yours last so long.
Question: can you get off Kisqali and find an alternative?
I wonder if getting off it would change the afib.
I will be praying for you, Zebra. I will be praying that if theres another alternative that it would be brought to your attention.
Its troubling when the “cure” is worse than the disease and can create another problem for you.
Theres so much info out there it can be very unsettling.
Please keep us informed.
You are loved. ❤️
May God bless you with His Kindness and care.🌹

Awww. Thank you so much for your kind thoughts and words. The question about the meds will be one I have for the cardio EP. Yes, sometimes meds seem like a symptom exchange program. Are you willing to trade x for y and z? 🤔 Thanks for the prayers! We’ll see how this plays out.

I'm taking them as well, but my bone metastatic gets worse. Is your stage three or four? Do Kisqali and letrozole work well to control your cancer?