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Concerned that I have hit BCR

Prostate Cancer | Last Active: Oct 4 7:50pm | Replies (48)

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Profile picture for jeff Marchi @jeffmarc

3 1/2 years after surgery, my PSA hit .2 and I had to have salvage radiation. There’s a good reason to get it at that level. Don’t wait too long. Here are some information about that.

From Ascopubs about what PSA to do salvage radiation.
≤0.2 ng/mL:
Starting at this level maximizes disease control and long-term survival. Patients treated at PSA < 0.2 ng/mL achieve higher rates of undetectable post-SRT PSA (56-70%) and improved 5-year progression-free survival (62.7-75%).
Delaying SRT beyond PSA ≥0.25 ng/mL increases mortality risk by ~50%.

0.2–0.5 ng/mL:
Still effective, particularly for patients with low-risk features (e.g., Gleason ≤7, slow PSA doubling time). The Journal of Clinical Oncology recommends SRT before PSA exceeds 0.25 ng/mL to preserve curative potential.

0.5–1.0 ng/mL:
Salvage radiation remains beneficial but may require combining with androgen deprivation therapy (ADT) for higher-risk cases.

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Replies to "3 1/2 years after surgery, my PSA hit .2 and I had to have salvage radiation...."

Agree.