Hi. I can tell you that a new infectious disease doctor told me to not take a cholesterol and anti reflux meds while taking the big three. He also recalculated the dosage and found that, based on my weight, the original Dr had me on too much so he reduced one of them. The pharmacist also told me to space the meds at least 4 hours apart. I’m following their advice and so far so good. 🙏🏻. The first month when I was taking all meds it didn’t go well. Now, with the change it’s good. I hope that helps.