I haven't taken Enhertu, but I was on a clinical trial of a copycat drug. (It didn't work for me.). Before every infusion they gave me the anti-nausea drug Aloxi and the steroid dexamethasone.

I didn't really feel bad at all, but I wonder if feeling bad might be a sign that it's working. The one clinical trial I have been on that worked on my cancer made me feel awful. And as it stopped working, I started to feel better.