Good luck with new medication @jig4891. I have tried anastrozole for a year, exemestane for another year. Now I’m on Letrozole. If Tamoxifen doesn’t work out, try exemestane. I was ok with exemestane until BMX, then I experienced petechiea. My onco said it could be because of the trauma caused by the surgery. She said if Letrozole doesn’t work out, I can try exemestane again. So far I have mild joint pain, aura headache every few weeks. Keep trying until you find something that you can tolerate.🤗

Lots of luck to you on your 3rd attempt with these meds. I was Stage 1A and decided to go the mastectomy route. I did not need radiation and chemo as my oncotype score was 2. I started on Anastrozole and was on it for about 1 year 3 mos before I got carpal tunnel in both arms and a bad case of DeQuervain's tendonitis. It also triggered some arthritis in my thumbs so quite debilitating. This caused my oncologist to try switching to Letrozole but this made things even worse. So, we took a brief break at which time my symptoms seem to get better. We then tried Tamoxifen for about 5 months but I got the most painful crippling calf cramps that made it too painful to walk at times so I stopped. So, I have decided to stop taking these meds since April and am feeling so much better. So I was on the drugs for basically 2.5 years. I felt I gave it my best but not being able to function using my arms and legs was the primary decision. I did not consider this living as I was in so much pain every day and unable to do everyday chores. So, to me there needed to be a balance of quality of life. Of course, it was not an easy decision but I am just glad the muscle/joint pains/tendonitis has gone away as I was truly afraid it would become permanent. The drugs did result in osteoporosis in my left arm so I am trying to address that by exercising more now that I can. I was fortunate that it did not lead to osteoporosis in my spine/hip. I wish you well in our venture too.