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How long does your oncologist have you on ADT?
Prostate Cancer | Last Active: Sep 28 12:11pm | Replies (69)Comment receiving replies
Actually, you become castrate resistant and ADT no longer keeps your PSA down, Even though you are castrate resistant, not every cell is castrate resistant as you mentioned.
You then begin an ARSI Because they are capable of keeping the PSA down, even if castrate resistant.
I’ve been castrate resistant for six years, If I reduce my main ARSI drug, my PSA rises immediately. I was on Zytiga for 2 1/2 years. I tried reducing from four pills to three to see if it would help with the brain fog. My PSA went from .2 to 1 in 18 days because I had reduced the ARSI.
I stopped taking Orgovyx For eight months. Darolutamide Kept my PSA undetectable the whole time. That’s because Darolutamide works even if there is testosterone. (Other lutamides too).
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Your posts are very informative. You seem very knowledgeable. Is this from being an informed patient?
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I did not say every cell is castrate resistant. For many men who started their metastatic cancer treatment 6, 7, or even 8 years ago. The treatments was different. The medical community would start you on Casodex for 30 days and then start you on ADT. At some point resistance would set in and they would offer chemo. PSA would go down and then start to rise. Then they would start you on an ARSI like Xtandi and the ARSI would keep the cancer under control for many years - hopefully.
Now - triplet therapy has replaced doublet for high volume metastatic prostate cancer. You get all the treatments up front and they are hoping for longer deep remission.
I was told by my doctor if I ever started to become resistant they would not stop ADT or Darolutamide. I believe Darolutamide is a miracle drug and is superior to the other ARSI's.