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Post Evenity DEXA numbers

Osteoporosis & Bone Health | Last Active: Aug 7 11:06pm | Replies (144)

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These are very impressive gains— congratulations!

I've read that a few members on this forum followed a similar path: they used Evenity first, then transitioned to Prolia for 2-3 injections in hopes of achieving further BMD gains. Based on their posts, they're planning to switch to Reclast after completing the Prolia doses.

Your endocrinologist makes a valid point about taking a one-year "sabbatical" from Evenity. I believe it was during last year's Santa Fe Bone Symposium that several specialists mentioned the idea that "bone doesn't want to keep building" indefinitely.

There is a clinical study (small) that looked at a sequence of Evenity → 2 Prolia injections (1 year) → Evenity. BMD outcome is shown in the graph below. The full publication link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6877701/
Keep in mind, though, that this study used a shorter duration of Prolia than what your endocrinologist is proposing. As many of us now know, the risk of rebound bone loss increases with more doses of Prolia. If you end up having four injections, will Evenity's antiresorptive effect be strong enough to counteract a potential rebound? That's definitely something worth discussing with your endocrinologist.

Are you able to take a bisphosphonate orally?

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Replies to "These are very impressive gains— congratulations! I've read that a few members on this forum followed..."

Thanks for your comments! The curves are encouraging! Wish there was a comparison between Prolia and Reclast as transitional medicine. I may just do the Prolia-Evenity sequence. I have meeting with my Dr at 6 months interval to evaluate Prolia efficacy. I’m sure she won’t object to 2 does if necessary.

I can take bisohosphonate orally I’m sure but my main goal is to build bone as fast as I can and also to avoid fractures. I don’t want to go through that again!

I forgot to post my TBS. Here you go. It seems I’m not that good yet. My Dr said it will improve with bone build.

I've had two injections of prolia following Evenity. Prior to that forteo then alendronate.
I am 77. Too soon to go on prolia til I die. Thinking about low dose reclast to counter prolia rebound. Then what? Thoughts, ideas? My endocrinologist is not very creative in his thinking. I have until November to decide. Thanks everyone.