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Cribriform cells: Does their presence change treatment approach?
Prostate Cancer | Last Active: Jul 28 2:26pm | Replies (88)Comment receiving replies
I have read about this and this part was quite informative
SBRT is an excellent option for most localized prostate cancers, but for tumors with a cribriform pattern, the risk of recurrence is higher and SBRT may not fully eliminate the cancer. These cases often require more aggressive or combined treatment approaches, and decisions should be made in consultation with a specialist. As a result surgery is recommended for localized cancer.
EBRT is also recommended with a little bit higher dosage than without cribriform.
Replies to "I have read about this and this part was quite informative SBRT is an excellent option..."
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This was a small but interesting study. The only one I could find that compared cribiform with and without IDC.
https://pubmed.ncbi.nlm.nih.gov/31059665/
The study was too small to be definitive, but hopefully it leads to more studies.
My MO at the University of Cincinnati was the one who got me interested in it. She said when she sees cribiform she looks for 2 things;
- accompanying IDC or
-PTEN loss (on Decipher)
If either are present she treats it much more aggressively.
Obviously she didn't dismiss the need for treatment with cribiform. But she said alone it raises a yellow flag. In conjunction with IDC or PTEN loss, it's a red flag.
It's interesting that historically, IDC (much more aggressive) was lumped with cribiform and it wasn't until 2016 that the WHO recognized them as 2 distinct findings.
It was confusing to me when diagnosed because Dr. Google told me it was basically a death sentence but the none of the doctors I consulted with felt it would change there approach to therapy. The one thing it certainly did was rule out active survellience.