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Cribriform cells: Does their presence change treatment approach?
Prostate Cancer | Last Active: Jul 28 2:26pm | Replies (88)Comment receiving replies
I will look for the studies. There have been a number of them. I have 4+3 with cribiform.
I had SBRT without adt.
Cribiform still isn’t fully understood. We know it is more aggressive but how much more is depends on a number of factors.
-no IDC
- no hypoxia in tumor
- basal immune subtype of tumor
- no PTEN loss
The PTEN and IDC were the biggest factors. PTEN loss amplifier of aggressiveness
I’m not a doctor, but as they say
“no two cancers are alike”.
I was fortunate to have an oncologist dig into my case as an individual.
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I have read about this and this part was quite informative
SBRT is an excellent option for most localized prostate cancers, but for tumors with a cribriform pattern, the risk of recurrence is higher and SBRT may not fully eliminate the cancer. These cases often require more aggressive or combined treatment approaches, and decisions should be made in consultation with a specialist. As a result surgery is recommended for localized cancer.
EBRT is also recommended with a little bit higher dosage than without cribriform.