PSA does go up and down a little. Wait a couple of future tests and see what is happening. You shouldn’t wait more than three months between blood tests If you think it’s rising. I’ve gotten them every month for eight years.

You do not have to do anything until your PSA reaches .2. You just went up .01 which is pretty insignificant.

I attend advanced prostate cancer weekly meetings with Ancan.org. Frequently people come in with small changes in their PSA that they are just panicked about. And the vast majority of cases, it means nothing and they do not have a consistent rise in PSA. Talk about longevity, Couple of months ago one guy came in and he was a Gleason nine and his cancer came back following a prostatectomy, 30 years later.

In your case with such a low volume of cancer, it’s possible they did get it all.

During the latest PCI conference, the following was discussed. Dr’s Kwon and Moyad agree to this. Seeds for metastasis were already there when surgery was done, waiting to grow.

I am also a 4+3. It took 3 1/2 years before my first reoccurrence after prostatectomy.

It is also possible that your cancer is coming back. The cribriform is a real problem and can require radiation after surgery to really eliminate it, in some cases, like after SBRT.

Research indicates that the presence of cribriform morphology, especially when it's extensive, is a strong predictor of biochemical recurrence after radical prostatectomy.

The presence of cribriform pattern can help doctors identify patients at higher risk of recurrence who may benefit from more intensive post-operative monitoring or treatment strategies.

A lot of this is just things to think about and discuss with your doctor.