@meow Dr. Patterson's team has me on LDN total time now about 6 weeks. I was at 1.5 and stepped up to 2.5 and just last night stepped up to 4.5. Dr. Bream (on Patterson's team) told me that 'many people' are going to feel a difference (if it works for them) at 2.5 (like a doorway you step through). At 2.5 I can't say that I felt a difference thus the step to 4.5. We shall see what happens at 4.5. As you likely know, Naltrexone is a drug designed to help people with addictions, but those dosages are north of 20 miligrams so those of us who are trying it are truly Low Dose Naltrexone.