← Return to Cribriform cells: Does their presence change treatment approach?

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Thank you for replying! My Husband has a PSA of 8.5 and Gleason score of 7 (3+4) GS4 being less than 5%. Contained in both side prostate. My Urologist is one of the best in Mississauga where I live. While some surveys indicate wait time of 6 months for GS 7 should be ok, other surveys say time does matter, even a few months in the final outcome.. I hear that North York Hospital has least waiting times, so trying to check that out tomorrow. Advice from Canadians on this forum will be much appreciated.

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Replies to "Thank you for replying! My Husband has a PSA of 8.5 and Gleason score of 7..."

The good news is that Gleason 3+4 is borderline: it's the lowest score that oncologists are even willing to call prostate cancer (it's lower risk than 4+3, which is also Gleason 7).

One likely recommendation is what they call "active surveillance", which means just more-frequent blood tests and scans to keep an eye on it. If PSA hits 10 or so (depending on the oncologist), they might consider trying some medication, but I think it would be less common to jump straight to surgery or radiation with only a 3+4 score.

The other good news is that the long-term survival rate for Gleason 3+4=7 with treatment is somewhere over 99%, I think.

There are probably cancer patients who need treatment urgently being triaged ahead of your husband, so in a sense, it's good news that they're not in a rush to see him, even though the wait is stressful. For me in 2021 it was straight into a hospital bed, being wheeled back and forth on a stretcher for a few days for endless tests and imaging while they tried to figure out what was happening, rushing into the operating room in the wee hours for 10+ hours of emergency surgery, then 3 1/2 months before I was stable enough to be allowed to go back home. Trust me, you don't want to be in a situation where they're eager to take him in a hurry. 🙂

In the meantime, many people in the forum have found this book very helpful for understanding prostate cancer, including your husband's situation. It's well worth a read (even though things have already changed a bit just since it was last updated in 2023.
https://www.amazon.ca/Patrick-Walshs-Surviving-Prostate-Cancer/dp/1538726866

Hi, based on the research I have done for my prostate cancer diagnosis, I think your Urologist is giving you good advice. With a Gleason score of 3+4 and cancer that is contained to the prostate, active surveillance could be one of the options available. I don't say this to suggest this treatment option, but rather to indicate that from the information you have provided, his form of cancer is not aggressive and not likely to progress significantly in six months or likely even longer.

I am also from Canada (central Alberta). Before having a biopsy, I had a PSMA MRI, which detected a small lesion that extended outside the capsule of the prostate. A subsequent biopsy confirmed that the lesion was cancerous (Gleason 4+3) with Cribriform Pattern 4 present. I had a subsequent PSMA PET Scan that showed no indication of spread. Because my cancer had more aggressive indicators than your husbands (i.e., it extended outside of my prostate capsule, was Gleason 4+3 and had Cribriform pattern), I definitely required treatment and had a robot assisted radical prostatectomy on July 14th. My follow-up pathology showed no cancer in any of the margins of what was removed or in removed lymph nodes and seminal vesicles. This was good news and post surgery pathology is standard testing that they will do if your husband opts for surgery.

A few things to consider:
1) Check if the biopsy results mention anything about Cribriform Pattern, which is a more aggressive form. If it was not found this is a good sign.
2) If your husband had a PSMA MRI test before getting a biopsy, this provides an image of prostate and whether the cancer is confined to the prostate or may have spread to surrounding tissues. I was not sure what you meant by "Contained in both side prostate", but if you meant that the cancer is confined to the prostate this is also a good thing.
3) I did a lot of online research from reputable sites and spoke to two different urologists, but I still wasn't sure I knew enough about the treatment options to be sure that a prostatectomy was the best option for me. I decided to book private consults with a urology surgeon and a radiation oncologist at the Mayo Clinic. It cost me a few thousand dollars US, but I was able to get all of my questions answered within a couple of weeks and I am very happy I did it.
4) If your husband decides on a prostatectomy, make sure he gets a robot assisted radical prostatectomy or RARP and not an Open prostatectomy. While research may indicate that the outcomes may be similar, the recovery is much faster RARP.
5) I suggest at least checking into active surveillance as a treatment option, if only to give you comfort that your husbands cancer, based on what you posted and my understanding as a fellow patient only, is likely to progress slowly.

I empathize with you because I found the uncertainty on not being sure what to do and then not being sure when it will be done to be the hardest part.

I wish you and your husband all of the best.