I could not find the exact post, but below is part of another post that is essentially the same information. It will be interesting to see how my body reacts to the next dose in a year or two. I also added one Claritin per day 2 days before the infusion, the day of, and 2 days after to reduce the risk of the acute phase reaction that so many have experienced. I did not want to take steroids, as they are not good for the bones. My infusion was 45 minutes, not 60, and I began taking the 650 mg of Tylenol 2 days before as well and then followed the daily regimen below. That way it was already in my system, and the nurse did not have to administer it. Good luck to you!

First, I order the infusion nurse to dilute the 5 mg of zoledronic acid (which comes in 100 mL of D5W) into 500 mL of NS (normal saline), thereby diluting the drug from 5 mg% to 0.8 mg%. Then I order it to be administrated over 60 minutes, instead of 15 minutes. Giving an N-BP more dilute and more slowly makes it even safer for the kidneys. The 3rd thing I always do is order the infusion nurses to administer 650 mg of acetaminophen to the patient during the infusion, and I tell the patient to take at home the same dose of acetaminophen (two regular strength Tylenols) with dinner and at bedtime the day of the infusion, with all 3 meals and at bedtime the day after the infusion, and a final (7th) dose with breakfast the 2nd morning after the infusion. These 8 doses total of acetaminophen reduce the chance of a symptomatic APR from 20-30% to < 1%.