@wr61
My PCP stated Mayo required me to start at lowest dose and it was one shot per week. I lost no weight entire month. To be honest gained a lb. What I felt was a slight decrease in appetite for dinner. No suppression for breakfast or lunch. No reduction for snacks. I did start to have a change to bowel movents from once a day to every couple of days.

I went all the way from lowest to highest with no reduction in weight. My PCP stated I was one of those that did not react to the drug. Then after a delay starting the highest dose (wife was sick) took the 2.4 dose after 3 months of lower doses.

About 2 hours (was around 10 p.m.) felt stomach upset. Went to bed woke up in morning with nausea and vomited. Called Mayo PCP and got an afternoon appt. Vomited prior to leaving for appt. Told could not go on nausea pill due to other medication on. Given guidance on eating and having to wait for medication to leave body (which was weeks). Giving warning to drink electrolytes.

Got home around 5 p.m. and vomited. I guess unlucky one who had no reaction to drug all the way from .25 to the start of 2.4 and then the reaction to 2.4. Took about a month for me to return to normal.

My PCP asked if I would be interested in ZEPBOUND. He said had to appetite suppresors instead on one that WEGVOY had. I said no. Now months later struggling with weight. I am a very active person and was told if could keep my fitness level up could take my time losing weight.