Hi! When I first got cancer I was put on folfox and had an allergic reaction to the ox my 2nd round and had to stop. But I did get the cold sensitivity and neuropathy in my hands and feet. The second round I couldn’t walk for hours. Needed 2 people to get me to the car and walk me to my door and couch. Thank goodness my son is strong! I had a breathing issue and almost went into anaphylactic shock in the office. After an additional 10 rounds of just 5FU I went 8 months and then it recurred in my vaginal area and nodes. I now am on folfiri and get mouth sores and massive diarrhea but its a better trade I think. Will be on it for life as maintenance.