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How long does your oncologist have you on ADT?
Prostate Cancer | Last Active: Sep 28 12:11pm | Replies (69)Comment receiving replies
Orgovyx and Lupron work almost exactly the same. I’ve been on both of them. There’s been no difference in any reaction/side effect.
Now, if you want to get off ADT, you could look at the patch study and consider using estradiol patches which work just as well, but have many fewer side effects.
You would find that Nubeqa Works almost identically with Xtandi But has fewer side effects and does not pass the blood brain barrier which reduces the amount of brain fog. Unfortunately, if he stays on ADT, the brain fog can continue But it won’t be as bad. I’m on Orgovyx and Nubeqa And after 15 years, I’ve been undetectable for the last 20 months while on Nubeqa. I know a lot of people in their 80s that have switched to using that alone, It works, even if you have testosterone. Something to discuss with your doctor.
If you Would like to hear more about it you could join an advanced prostate cancer weekly meeting at Ancan.org. And get some information about what works for people in their 80s.
Replies to "Orgovyx and Lupron work almost exactly the same. I’ve been on both of them. There’s been..."
Thank you for that information. We’ll discuss with my husband‘s oncologist next week. The main concern is the rise in the PSA. Dana Farber was not happy until he went down to 0.02. (If I’m printing that correctly). It is now at 0.01. They told him the chance of spreading at a higher number, was likely. He was diagnosed on Valentine’s Day, of this year, 2025, been on the medication’s as of 1 March.
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"Orgovyx and Lupron work almost exactly the same. I’ve been on both of them. There’s been no difference in any reaction/side effect."
True: the side-effects of low testosterone are similar, regardless of what's causing it.
The main difference is that Orgovyx is a GnRH receptor antagonist like Firmagon (they both block glands from receiving gonadotropin to stimulate testosterone production) while Lupron is a GnRH analogue or agonist (it mimics gonadotropin to desensitise the glands).
The downside of a GnRH agonist is that it causes an initial testosterone surge before the testosterone falls, and that is potentially a huge problem if your prostate cancer is already in a precarious situation (e.g. my metastasis was compressing my spinal cord); in that case, a GnRH antagonist like Firmagon or Orgovyx is a safer choice. There are some ways to block that surge with additional medications, but they still delay the actual testosterone *reduction*, so it's still longer before your cancer can start responding with Lupron than it is with Firmagon or Orgovyx.