I am sorry to hear about your wife's diagnosis. The best treatment for any pancreas cancer that has spread is chemotherapy. We rarely offer surgery to patients with disease outside of the pancreas, although we will consider this in selected patients. This is usually a patient who has very small volume liver disease (1 - 3 small lesions that can also be treated) that has been stable or has disappeared on 9-12 months of chemotherapy. I would encourage your wife to continue with chemotherapy and, depending on how she responds, she could be evaluated in the future to see if surgery may be an option.