Like others here, I also have had issues since my infusion about 15 months ago. For me, it's my right leg that has had flareups that are much worse at night. I also assume it's because I am not moving and then when I do it's incredibly painful. Same when getting up after sitting too long as in being in a car or other situation. Once I get moving, it's better but never completely goes away. I've been doing exercises provided by PT to improve muscle strength as now my right knee shows osteoarthritis. Some I stopped as it seemed to make matters worse. At this point, I don't see how it will ever improve to where I was before the infusion.