I had my first Reclast infusion Wednesday, July 16th. This group was instrumental in my preparation for the infusion. I began hydrating well a few days before, in addition to starting the 650mg Tylenol and Claritin regimen that was recommended by one of the posters here (she had the protocol of the physician who ran the clinical trials). My endocrinologist and I had the same discussion about dosage, as I am very petite. But he felt it was important for me to begin with the 5mg. The nurse initially told me the infusion would be 30 minutes, and I said I needed it to be at least 45. She was fine with that. I had the saline flush prior to and after the infusion. I will continue the hydration, Tylenol, and Claritin regimen over the weekend and then call it good. I felt a bit of "something/twinge" for a brief period the day of the infusion, but nothing else. It was fleeting and did not cause concern. I am so grateful for this group!