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Gabepentin vs. Lyrica vs. Cymbalta?

Posted by seamusmacd @seamusmacd, Jan 30, 2024

Hi, I was diagnosed by my neurologist with "Idiopathic small fiber sensory neuropathy " in my feet ankles and a little in my hands. For me that means continual mild numbness of both feet and now and then tingling in my hands. Also very painful foot cramping when I go horizontal making sleep tough. After reading through this group I'm not too hopeful on finding a remedy. I'm currently on 1800 mg of Gabepentin daily, and don't think it is doing much if anything. The doctor suggested starting there and perhaps switching to Lyrica or Cymbalta. Most curious about Cymbalta for cramping pain since I think Lyrica will be fairly similar to Gabepentin... Does Cymbalta help with foot cramping and pain? Thanks!

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Mary Ann | @crissma | Jul 14 12:15pm

I never thought of those side effects from Cymbalta. I’ll need to look into it. I’m also going to talk to my PCP about the Lyrica. I’m down to 600mg of Gabapentin I’m hoping to move to 400mg soon. I’m 66! Can’t believe it!

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danny67 | @danny5 | Jul 14 3:48pm
In reply to @horsehair "I'm so glad that the Gabapentin & Cymbalta are working for you. I switched from just..." + (show)
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I'm so glad that the Gabapentin & Cymbalta are working for you. I switched from just Gabapentin (already on both Effexor & Wellbutrin for depression, though my psychiatrist wants to wean me off one of them) to Lyrica for nerve pain. It works 100% most days, but I have to say that the longer I am on it, the more noticeable the side-effects are: Dizziness, confusion, memory and cognitive impairment. I know it is not just me worrying because my daughter who lives with me said that she correlates these two occurring together. I am "only" 60, LOL, and I just don't think this should happen. I am ready to ask my primary care physician to wean me off of it, as I'd rather have the pain than have mental/memory impairment. Since reading your post, I am going to ask my psychiatric dr. if I can make the switch. So, before you possibly in the future ever consider Lyrica, I just wanted to let you know these side-effects are reported by others I have noticed.

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i have no interest in changing to Lyrica. i've just heard about the side effects recently. no thanks.

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horsehair | @horsehair | Jul 14 4:15pm
In reply to @crissma "I never thought of those side effects from Cymbalta. I’ll need to look into it. I’m..." + (show)
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I never thought of those side effects from Cymbalta. I’ll need to look into it. I’m also going to talk to my PCP about the Lyrica. I’m down to 600mg of Gabapentin I’m hoping to move to 400mg soon. I’m 66! Can’t believe it!

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Oh, I was talking about those terrible side-effects from Lyrica, not Cymbalta, which I've never tried.

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