1st PSA test seven weeks after surgery

Posted by johndavis60 @johndavis60, Jul 11 3:08pm

Hi All, this morning I did my first PSA test after prostatectomy. I had positive margins and will be doing ADT and radiation soon, but doctors wanted baseline psa first. Reading just came in at 1.1.
Isn’t that a bit high? They didn’t want to wait 3 months because I have pt3b and other high risk findings in biopsy/prostatectomy , although all 19 nodes they took out were negative. I already messaged my doctors but they may not answer right away. Don’t want to panic all weekend long.
Thanks:)

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Profile picture for northoftheborder @northoftheborder

The OP seems to have non-metastatic castrate-sensitive prostate cancer (nmCSPC). I can't find anywhere that says Abiraterone (Zytiga) is approved for that, but I may have missed something.

As @jeffmarc and @thmssllvn wrote, Abiraterone has been approved for metastatic castrate-sensitive prostate cancer (mCSPC) for quite a few years. Apalutamide (Erleada), Enzalutamide (Xtandi), and Darolutamide (Nubeqa) are also approved for mCSPC.

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Hi @northoftheborder ,
I have my first MO meeting on Wednesday, I’ll reply to this thread when I know what the plan is. My RO suggested that I may be prescribed multiple ADT drugs but did not elaborate, although he agrees with me that my cancer needs to be fought very aggressively due to all the negative findings during biopsy and prostatectomy. All 19 of my lymph nodes taken out during surgery were clean but it’s just a matter of time until problem gets worse with out aggressive treatment. For example, I have LVI so that will need to be addressed. What is the best way to do that? Hopefully MO will know.
Thanks!

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John - you will be fine . The 1.1 PSA is due to the fact your fresh out of surgery which is quite common . But if they want to do your EBRT with ADT right away ( due to concerning features ) , that should be fine . There are so many therapies now , so try not to worry too much . Keep close to your Dr's and ask lots of questions . God Bless Sir .

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Profile picture for johndavis60 @johndavis60

Thanks @topf , That is my understanding as well. This also my expectation that I will be on ADT medications for 3 years. I also sugggested to my doctor that I should do docetaxel but not sure she will go for that yet. I feel like another PSMA PET scan should also be done.
Thanks!!

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May I ask what kind of facility you are going to and what research type hospitals are in your area? I will finish my 6 month ADT and radiation journey tomorrow with my last Orgovyx pill. If I had to do it all over again I would choose our local Comprehensive Cancer Center hospital. Best wishes on your journey.

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Profile picture for chippydoo @chippydoo

May I ask what kind of facility you are going to and what research type hospitals are in your area? I will finish my 6 month ADT and radiation journey tomorrow with my last Orgovyx pill. If I had to do it all over again I would choose our local Comprehensive Cancer Center hospital. Best wishes on your journey.

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Thanks @chippydoo ,
I get all my treatment at the University of Rochester Wilmot Cancer Center. This is Rochester, NY not MN.

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Profile picture for johndavis60 @johndavis60

Thanks @chippydoo ,
I get all my treatment at the University of Rochester Wilmot Cancer Center. This is Rochester, NY not MN.

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Great to see you are in a good facility.

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Profile picture for johndavis60 @johndavis60

Hi @northoftheborder ,
I have my first MO meeting on Wednesday, I’ll reply to this thread when I know what the plan is. My RO suggested that I may be prescribed multiple ADT drugs but did not elaborate, although he agrees with me that my cancer needs to be fought very aggressively due to all the negative findings during biopsy and prostatectomy. All 19 of my lymph nodes taken out during surgery were clean but it’s just a matter of time until problem gets worse with out aggressive treatment. For example, I have LVI so that will need to be addressed. What is the best way to do that? Hopefully MO will know.
Thanks!

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Wishing you good luck and great consultations on Wednesday ! Hope you get great answers and a clear way forward. Try to keep in mind that newer and newer treatments are emerging every day :), and we all here just need to "buy some time" till super efficient protocol for a complete cure is found < 3.

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Profile picture for johndavis60 @johndavis60

Thank you @michaelcharles ! i believe the RO’s plan is to radiate me over 37 sessions.
I also had a PSMA pet scan prior to surgery and they found no spread so hopefully the radiation and other treatments will keep me alive until 60 ( I’m 50 now). Thanks again:)

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Let's aim for survival well into retirement! 🙂 Treatments continue evolving. Blessings on your journey.

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I too am a pT3b and my doctor was kind of casual...unaffected...and said "we'll have to talk about radiation in your next appointment." That was end of April, and I see him at the end of July. Your doctors seem concerned for you based on the pT3b category. I wonder why my doctor is not as concerned? And...
I specifically asked before surgery if my urologist was going to remove one or more lymph nodes? He said" No, the overwhelming evidence with catching cases like yours early like we've done, has proven time and again, that we do not need to remove the lymph nodes. He cited a few studies of ~2,000 men who were Gleason 3+4=7 and it showed that removing the lymph nodes always came back as "negative"...no metastasis to the nodes. But...my doctor was operating on the fact that I was a Gleason 3+4 = 7, "before" he got my pathology report that revealed I was actually a more aggressive pT3b patient. My seminal vesicle invasion was only in the left seminal vesicle, and was minimal with no tumor or advanced disease...maybe that is why he felt comfortable waiting three months. Everything is hind sight now, b ut I will ask him. I have rather assertively asked him pointed questions before, and he seems to always "poo poo" the basis of my question, saying "you should not read the internet about this disease. The majority of the internet is full of misinformation that will get you worried for nothing. I don't know who to believe.

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Profile picture for rlpostrp @rlpostrp

I too am a pT3b and my doctor was kind of casual...unaffected...and said "we'll have to talk about radiation in your next appointment." That was end of April, and I see him at the end of July. Your doctors seem concerned for you based on the pT3b category. I wonder why my doctor is not as concerned? And...
I specifically asked before surgery if my urologist was going to remove one or more lymph nodes? He said" No, the overwhelming evidence with catching cases like yours early like we've done, has proven time and again, that we do not need to remove the lymph nodes. He cited a few studies of ~2,000 men who were Gleason 3+4=7 and it showed that removing the lymph nodes always came back as "negative"...no metastasis to the nodes. But...my doctor was operating on the fact that I was a Gleason 3+4 = 7, "before" he got my pathology report that revealed I was actually a more aggressive pT3b patient. My seminal vesicle invasion was only in the left seminal vesicle, and was minimal with no tumor or advanced disease...maybe that is why he felt comfortable waiting three months. Everything is hind sight now, b ut I will ask him. I have rather assertively asked him pointed questions before, and he seems to always "poo poo" the basis of my question, saying "you should not read the internet about this disease. The majority of the internet is full of misinformation that will get you worried for nothing. I don't know who to believe.

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Some doctors wait for three months to allow you to heal after surgery.

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Profile picture for jeff Marchi @jeffmarc

Some doctors wait for three months to allow you to heal after surgery.

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That makes sense. I had to wait one month after my spinal surgery before I was allowed to have the post-op SBRT there (20 gy).

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