@northoftheborder
Hope you guys are still our friends up there! I took several cruises out of Vancouver and loved Canada.

I agree with you. I sometimes crinch when I hear posters post they only had radiation on certain areas of prostate. My R/Os at Mayo and UFHPTI stated they radiate all areas of prostate and will add margins.

Why I asked? Because a biopsy will only show the cells where taken. It is almost impossible to take a biopsy of all cells in prostate. So you might miss a part of prostate that has cancer so we radiate all of prostate and margins regardless of the specific areas found by biopsies.

I researched this to find we are talking about cancer at a cellurar level. So my little prostate got radiated along with my margins. It seems to have worked as my PSA last test was .10 when before treatments was 3.75.

I agree with your assumption of the culprit being outside prostate when PSA rises. I think that is one of the things my urologist, PCP, and R/Os looked at when we all thought radiation was best treatment for me.