Retrospective studies can be hard to interpret, as they lack the ability of randomized controlled trials to eliminate bias. The high incidence of MACE is likely due to the prevalent underlying cvd among patients. Without a corresponding control group, it's difficult to draw a clear conclusion.

I had Forteo treatment, followed by HRT. I've asked an endo who uses HRT with his patients, and he felt it would be appropriate for me as long as I'm not at increased risk for cvd or breast cancer. Before I saw my cardiologist, I thought HRT wasn't an option for me - but neither he nor the other heart specialist had any hesitation in my case.