The data for those patients were retrospectively analyzed. They used 68Ga-PSMA PET/CT and considered factors such as androgen deprivation therapy, PSA doubling time, PSA before PET/CT, T−/N-category and Gleason score. So, they accounted for the status of the cancer.

You’ll find regular mention of PSMA PET being most useful at PSAs above 0.2 ng/mL (like here: https://www.petimagingflorida.com/helpie_faq/at-what-psa-level-should-i-get-a-psma-pet-scan/#:~:text=Generally%20speaking%2C%20PSMA%20PET%20Scans,levels%20above%200.2ng%2FmL.), which is why you’ll often see doctors wait until PSA of 0.2 before using PSMA PET.

The more aggressive the prostate cancer, the more PSMA avid uptake of the radiotracer there is. Also, the more aggressive the cancer, the more effective Pluvicto (Lutetium-177) is at treating it.