Hi Ed, When I started taking the protocol in Sept 2016, the numbness was just below my knees. After 2 months, the numbness seemed to be just above the ankles which is subjective on my part with no additional testing. Not really a dramatic improvement but the progression seemed to be stopped which was my main goal. Since then I'm still about the same except I do have some days where I actually have some feeling in the bottom of my feet. What kind of complicates the numbness feeling is that I was diagnosed with lymphedema in my legs in 2018 and have to wear compression socks which puts the squeeze on my legs and feet to keep the swelling down. I do think it's something that takes some period of time once you start taking the supplements because it's working on the restoring the peripheral nerve health vs how most of the neuropathy medications work by addressing the nerve signals to the brain (in my non-medical opinion).