I have been on Tymlos for 12 months and have had to lower my levothyroxine from 100 mcg to skipping a dose every other Sunday and last time I went to endo he wanted me to skip 3 x a month, but I was so tired on the dose of tymlos I refused. I lowered my tymlos dose to 60 mcg andhave a little bit more energy so I will go ahead and lower the levo doses. my TSH is 0.17 (I have no thryroid--) It makes me wonder what happens to my TSH when I got off Tymlos.