ANA tests for the presence of antibodies in general. ANCA tests for more specific antibodies. Here's some info from AI: 'The ANCA test, or Antineutrophil Cytoplasmic Antibody test, is a blood test used to detect and measure the levels of ANCA antibodies in the blood. These antibodies, which target proteins within neutrophils (a type of white blood cell), can indicate the presence of autoimmune diseases, particularly vasculitis and inflammatory bowel disease (IBD).'