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Husband’s low psa, aggressive Gleason 8

Prostate Cancer | Last Active: Jul 27 2:32pm | Replies (35)

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In my case, I was 68. PSA 7.9 Nov 2024, 10+ late Jan/early Feb 2025. Gleason 7 (3+4) unfavorable intermediate, no metastasis. On ADT Orgovyx since March 26, completed 5 sessions SBRT on April 9 - 22, July 7 PSA 0.36 -- if it becomes undetectable or less than 0.2 next To PSA, I want to go on ADT holiday. (My oncologist told me last April that we'd see if I get off Orgovyx after 8 months or a year; I prefer 8 months or sooner.

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Replies to "In my case, I was 68. PSA 7.9 Nov 2024, 10+ late Jan/early Feb 2025. Gleason..."

I too had SBRT 5 sessions. I stopped Orgovyx after 12 months. I was Gleason 9. After 3 1/2 months my PSA went up from 0.02 to 0.05. My T went up from 8 to 65.
Who is your oncologist? Not all oncologists believe in Intermittent ADT. I may want to talk to your oncologist for a 3rd opinion who believes in taking a holiday from this powerful drug!