My rheumatologist, who it took me 4 months to get in to see, told me it wasn't necessary for me to split my dosage AM/PM as my regular GP had suggested I do, to help with the night pain. So I tried the rheumatologist's advice for a month just to see if there was any difference and have been waking up with very, very stiff wrist and shoulder and achy all over. So last night I went back to the old AM/PM split routine, and voila, hopped out of bed this morning feeling fine. I started at 25 mg last December and go down to 7 mg starting tomorrow. Wish me luck!