wden: Tell us more - did you have the infusion or experience issues?
My endocrinologist discussed this Tx for me. Since I was undergoing dental work (tooth extraction), we've delayed starting. I have a friend who had it with no problems.

How are you being treated for this? Osteonecrosis is very difficult to treat once it starts. Usually hyperbaric oxygen is used.

I've been on Xgeva about one year and, so far, have had no complications. My oncologist opted for treatments once every 3 months, rather than monthly. His thousands of patients have responded about the same as other documented monthly treatments without as much risk. This is my personal experience having stage 4 metastatic prostate cancer for a decade, a radical orchiectomy and the full range of drugs and targeted beam radiation, including Pluvicto.
Good luck, and do your homework to make the best decisions.