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Hi, @traceywinters, and welcome to Mayo Clinic Connect. I've had some explosive diarrhea with taking semaglutide (Wegovy) and felt concerned that it might get out of hand. I'm so sorry you are dealing with the fear of going in your pants. I can only empathize and say I really know that terror.

Do you have IBS-D or another diagnosis, traceywinters?

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Replies to "Hi, @traceywinters, and welcome to Mayo Clinic Connect. I've had some explosive diarrhea with taking semaglutide..."

IBS-C. Add in moderate size diverticuli in sigmoid colon. Going another route. Started Vital Gut Renew for intestinal lining support yesterday. Cut out the dairy group to start with and will introduce each food from that group one at a time, then go to the next food group. It will take a long time, but I am willing to put in the effort. I am not a fan of prescription drugs to begin with, but I have had some doozies in my time. I wouldn't doubt that the powerful antibiotics that were administered to me during my diverticultis attacks have wrecked my innards.