Surgery or Radiation for Intermediate Prostate Cancer?

Posted by ljbboston @ljbboston, Aug 6, 2024

I was diagnosed with low-grade and low-volume cancer in 2018, and placed on surveillance.
6/24/2024: Prostate biopsy after MRI
Now with third biopsy, cancer is Stage II, PSA 6.73
- GS 4+3 in 2 cores (left and lateral 8%, right target 25%)
- GS 3+3 in 2 cores (left and medial 30%, left posterior lateral 30%)
- Benign prostate tissue in 8 cores.
Scheduled for a PSMA scan at Dana Farber in Boston today. (8/6/24)

Have met with Doctors from Dana Farber and Mass General and thus far have been given two options: Surgery or HRFT Radiation (28 treatments over 6 weeks) with short term ADT.

Any thoughts or advice from those who have been through this would be most appreciated.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for robertmizek @robertmizek

Hi. Just checking in to see how you’re doing. If you haven’t already seen the surgeon, you may want to add this question to your list

“What is Plan B if plan a fails and cancer returns?”

The only non-medical advice that I’ll share is if you decide to go the surgery route and perhaps even the radiation route I would learn how to do and start doing Keagles before whatever procedure you go through. That advice was given to me by someone on this forum. I did Keagles for three weeks before my surgery. I was mostly continant a week after the catheter was removed. I continue to do keagkes each day and seldom am in a panic to find a bathroom.

Good luck on your journey. We’re here for you!

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Hello @robermizek
I had a PSMA Pet Scan at Dana Farber last week which showed no progression beyond the prostate, my doctor said these are about 85% accurate. So that is good news. Met with a surgeon today at Mass General who has been doing Robotic Surgery for prostatectomy procedures for about ten years. I am most concerned about being continant after the procedure. He said it takes time, one to two months to get back to a more normal daily urinary process. He said Keagle exercises and good core strength are key to bladder control. I also met with a Dana Farber doctor about radiation last week. They use the Ethos machine which seems to be state of the art. It uses precise MRI positioning, and they update the MRI information at every treatment date. Treatment will be 20 sessions over four weeks, along with 3 months of ADT. Still unsure of what road to take to a cure.

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Profile picture for ljbboston @ljbboston

Hello @robermizek
I had a PSMA Pet Scan at Dana Farber last week which showed no progression beyond the prostate, my doctor said these are about 85% accurate. So that is good news. Met with a surgeon today at Mass General who has been doing Robotic Surgery for prostatectomy procedures for about ten years. I am most concerned about being continant after the procedure. He said it takes time, one to two months to get back to a more normal daily urinary process. He said Keagle exercises and good core strength are key to bladder control. I also met with a Dana Farber doctor about radiation last week. They use the Ethos machine which seems to be state of the art. It uses precise MRI positioning, and they update the MRI information at every treatment date. Treatment will be 20 sessions over four weeks, along with 3 months of ADT. Still unsure of what road to take to a cure.

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Hi and thanks for the update.

The results of your PET-PSMA scan are hopeful! I’ve had two of these scans and been told that they typically don’t detect lesions smaller than a half inch which is probably where his 85% number comes from.

Have you had a decipher test or considered getting one so that you understand how aggressive the cancer is? I asked for one when I was originally diagnosed and was denied. Had I received one back then that showed the aggressive high risk cancer I’m dealing with now I would’ve initially opted for surgery as primary therapy and dealt with short term incontinance issues. My care team told me that generally speaking if “Plan A” is surgery and cancer returns, radiation can be “Plan B”. If however radiation is “Plan A” and that fails more radiation is often off the table and surgery is off the table too and other therapies may be necessary.

Anecdotally, I had salvage RP this past January at age 68. I was 90% continent within a week of having the catheter removed. I then used one lightweight pad each 24 hours to catch small leaks. I never came close to soaking a pad. I was extremely concerned about both the catheter and leaking urine and neither was much more than a short term inconvenience. I strengthened my pelvic muscles with easy to do Keagle exercises three weeks before surgery and continue to do those exercises even now even though I no longer need a pad and don’t leak.

Last thought, the second time around my case was reviewed by a tumor board consisting of both radiologists and surgeons who collectively recommended that my treatment involve surgery, then long term ADT, and “clean up” radiation. That made my decision an easy one.

Hope you are comfortable with whatever decision you make!

- Bob

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Profile picture for northoftheborder @northoftheborder

Yes, you're right that there's a lot of debate about how/whether to treat low-grade, early-stage prostate cancer.

There are many of us with high-grade and/or advanced prostate cancer here in the forum, but I don't think we're representative; it's just that people with more-dangerous cancer are more likely to seek out information and discussion groups. My radiation oncologist told me that about 5% of prostate cancers (1 in 20) are like mine: fast moving, strike people young, and often aren't discovered until they've already metastasised.

Obviously, for people in my situation, there's no choice: treat it aggressively, or die in a few years (or less; Canada's former Leader of the Opposition, Jack Layton, was diagnosed with advanced PCa in 2010 around age 60 and died in 2011). For people with very low-grade PCa, the choice is either active surveillance or (to be on the safe side), a few months of ADT, which will have no permanent impact once it wears off.

The tough decisions lie in the middle: what if your Gleason score is high, but the cancer doesn't appear to have escaped the prostate? Do you make a life-altering change like removing or radiating the prostate? There's no *wrong* choice, just the choice that works for you.

While I wish we'd caught mine at that early stage, I still don't envy you the decisions you have to make.

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I recall the past leader of Her Majesty's Loyal Opposition, the Honorable Jack Layton. When it was made public on the news, it was stated that he did not want to disclose what type of cancer he had, as his condition would be discouraging to men with similar disease. It's here in this support group that I learned belatedly that he had PCa. But did he have a second cancer (undisclosed) after PCa, that led to his demise?
I attended his state funeral.

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