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← Return to ADT and Castrate Resistance
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Prostate Cancer | Last Active: Sep 29, 2025 | Replies (31)
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My MO says the benefits of ADT begin to decline after a couple of years anyway and staying on it longer is less beneficial. Other posts here say if I go off and PSA starts to rise, I can start back or go on to another treatment. With my cancer being of the aggressive type, I just don't want to do anything that might give metastasis and foothold. But, one way to look at it, a rise in PSA is called a "chemical recurrence". If it rises, we would be on it very quickly. But, I'm still scared about all this.
Replies to "My MO says the benefits of ADT begin to decline after a couple of years anyway..."
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They initially told me the same: my ADT would probably stop working after 18–24 months. But as I mentioned earlier, adding ARSIs and other changes in modern treatment strategies have thrown the older SEER data that was based on partly out the window (newer data is starting to show the shifts).
Again, it's complicated and changing fast, and everyone responds differently. My RO has encouraged me to stay on ADT+Erleada because they're working (full functional remission still after 45 months) and I'm not suffering any serious side effects, but your situation is different than mine, and your MO may be looking at it from a different perspective.