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Prostate cancer stage 4 with bone metastasis now spreaded to liver
Prostate Cancer | Last Active: Jul 11 4:40pm | Replies (19)Comment receiving replies
In my dad's case it happened after taking enzalutamide for 15 months. If we would have picked different medication like abirateroen would have prevent it?
Also not sure if it is due to the treatment path we had Orchidactomy to start with and then chemo and enzalutamide.
Or combination of orchidactomy and enzalutamide.
Or instead of enzalutamide we would have gone for Lu 177 would have prevent it?
Replies to "In my dad's case it happened after taking enzalutamide for 15 months. If we would have..."
Did enz, 2 chemos Ra 233 then Abiraterone All failed over years
Awaiting LU 177 soon with God's help as I meet all criteria
https://www.novartis.com/news/media-releases/novartis-pluvictotm-demonstrates-statistically-significant-and-clinically-meaningful-rpfs-benefit-patients-psma-positive-metastatic-hormone-sensitive-prostate-cancer?utm_source=twitter&utm_medium=social&utm_campaign=PSMAAdditionPR2025&utm_content=static-image-news
First, I am sorry to hear this progression for your Dad - this cancer is a beast. I am curious to know how you discovered the transition to neuroendocrine? Via a new biopsy or blood test? I know there are a couple tests like CgA and ?Napsen, but not sure about other ways to confirm.
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I encourage you to do a search of the Internet using this search
what causes prostate cancer to become neuroendocrine
Here are some information you would find
Neuroendocrine prostate cancer (NEPC) can arise from two main pathways: de novo, meaning it develops independently, or as a treatment-emergent form (t-NEPC) from pre-existing prostate adenocarcinoma. A key driver of t-NEPC is androgen deprivation therapy (ADT), which is used to treat prostate cancer by inhibiting the androgen receptor, leading to the cancer cells developing resistance and transforming into NEPC.
The purpose of ADT is to reduce the amount of testosterone, The surgery did the same thing, Though testosterone does get created other places in the body. Zytiga takes it a step further and reduces testosterone even more. Does that mean that it is more likely to cause neuroendocrine than Enzalutamide, I can’t say, but since it acts more like an ADT Then maybe it is not a better solution to move to Zytiga.
I’m not sure anybody has a real answer to this question.