First, terminology……
> EBRT (external beam radiotherapy) is the general term for all types of external radiation - SBRT, IMRT, IGRT, VMAT, Proton, whatever…….
Yes, a number of studies indicate that IMRT vs PBRT have similar results with no discernible difference in complications or side effects. There are currently two clinical trials looking into this - COMPPARE and PartiQoL. The PartiQoL study has released interim results indicating comparable side-effects. (Nevertheless, even prior to those studies I chose PBRT due to its Bragg-Peak characteristics and success with other cancers.)
So, the decision isn’t “EBRT or not to EBRT,” the decision is actually “If EBRT, what type of EBRT: SBRT, IMRT, IGRT, VMAT, Proton…….”
As for whether or not to use ADT (for intermediate risk prostate cancer) with EBRT, radiation technology is so much improved over decades ago, that some studies show minimal differences: https://www.onclive.com/view/ebrt-with-or-without-stad-shows-improved-15-year-survival-in-prostate-cancer
Dr. Scholz talks about this in this PCRI interview: https://youtu.be/cyY0nHXvzGc?si=vkI-63iM-_ErI-c3
Another consideration is whether it’s preferable to front-load ADT with radiation treatment or backload it. This is a paper titled - “In Prostate Cancer, ADT After RT Better Than Before RT” - that was presented at the American Society for Radiation Oncology (ASTRO) 2020 Annual Meeting, that discusses whether (and why) ADT with (and after) RT leads to better outcomes than ADT well before RT (which is how it is usually given): http://www.medscape.com/viewarticle/940049
(For my localized, 4+3=7, PSA of 7.976, I had treatments during April-May 2021: 28 sessions of proton (@ 2.5 Grays each session) + 6 months of Eligard (April & July) + SpaceOAR Vue.)
Good luck with your decision!
Thanks Brian. I was looking forward to your comment because I knew it would come with more reading material. 😁
I think I'm pretty much there to proceed with radiation in a few months. IMRT vs PBRT will be the question. It was very obvious that my RO was much more comfortable with IMRT. This will be a decision for another day. I'm done with cancer for today.